MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include recurrent bacteria...

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Detalhes bibliográficos
Main Authors: Nehme, Nadine T., Schmid, Jana Pachlopnik, Debeurme, Franck, André-Schmutz, Isabelle, Lim, Annick, Nitschke, Patrick, Rieux-Laucat, Frédéric, Lutz, Patrick, Picard, Capucine, Mahlaoui, Nizar, Fischer, Alain, de Saint Basile, Geneviève
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824282/
https://ncbi.nlm.nih.gov/pubmed/22174160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-378364
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