Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency

PURPOSE: To investigate the clinical and functional aspects of MST1 (STK4) deficiency in a profoundly CD4-lymphopenic kindred with a novel homozygous nonsense mutation in STK4. Although recent studies have described the cellular effects of murine Mst1 deficiency, the phenotype of MST1-deficient huma...

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Detalhes bibliográficos
Publicado no:J Clin Immunol
Main Authors: Dang, Tarana Singh, Willet, Joseph DP, Griffin, Helen R, Morgan, Neil V, O’Boyle, Graeme, Arkwright, Peter D, Hughes, Stephen M, Abinun, Mario, Tee, Louise J, Barge, Dawn, Engelhardt, Karin R, Jackson, Michael, Cant, Andrew J, Maher, Eamonn R, Koref, Mauro Santibanez, Reynard, Louise N, Ali, Simi, Hambleton, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Astute Clinician Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769310/
https://ncbi.nlm.nih.gov/pubmed/26801501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-016-0232-2
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