Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

Acute myeloid leukemia (AML) remains a challenging disease to treat and urgently requires new therapies to improve its treatment outcome. In this study, we investigated the molecular mechanisms underlying the cooperative antileukemic activities of panobinostat and cytarabine or daunorubicin (DNR) in...

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Bibliografiska uppgifter
Huvudupphovsmän: Xie, Chengzhi, Drenberg, Christina, Edwards, Holly, Caldwell, J. Timothy, Chen, Wei, Inaba, Hiroto, Xu, Xuelian, Buck, Steven A., Taub, Jeffrey W., Baker, Sharyn D., Ge, Yubin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823972/
https://ncbi.nlm.nih.gov/pubmed/24244429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079106
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