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Highly Stereoselective Total Synthesis of Fully Hydroxy-Protected Mycolactones A and B and Their Stereoisomerization upon Deprotection
Unprecedentedly efficient and highly (≥98%) stereoselective syntheses of mycolactones A and B sidechains relied heavily on Pd-catalyzed alkenylation (Negishi version) and were completed in 11 longest linear steps from ethyl (S)-3-hydroxybutyrate in 12% and 11% overall yields, respectively, roughly c...
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Main Authors: | , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
2011
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3823500/ https://ncbi.nlm.nih.gov/pubmed/21412860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201002627 |
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