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Highly Stereoselective Total Synthesis of Fully Hydroxy-Protected Mycolactones A and B and Their Stereoisomerization upon Deprotection

Unprecedentedly efficient and highly (≥98%) stereoselective syntheses of mycolactones A and B sidechains relied heavily on Pd-catalyzed alkenylation (Negishi version) and were completed in 11 longest linear steps from ethyl (S)-3-hydroxybutyrate in 12% and 11% overall yields, respectively, roughly c...

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Bibliografiske detaljer
Main Authors: Wang, Guangwei, Yin, Ning, Negishi, Ei-ichi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823500/
https://ncbi.nlm.nih.gov/pubmed/21412860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201002627
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