HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

The present study identified a novel mechanism of induction of apoptosis in glioblastoma cells by scriptaid – a histone deacetylase (HDAC) inhibitor. Scriptaid reduced glioma cell viability by increasing Jun N-terminal kinase (JNK) activation. Although scriptaid induced activation of both p38MAPK an...

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Bibliographic Details
Main Authors: Sharma, Vivek, Koul, Nitin, Joseph, Christy, Dixit, Deobrat, Ghosh, Sadashib, Sen, Ellora
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823006/
https://ncbi.nlm.nih.gov/pubmed/19583803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00844.x
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