Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

Vascular dysfunction is emerging as a key pathological hallmark in Alzheimer’s disease (AD). A leaky blood–brain barrier (BBB) has been described in AD patient tissue and in vivo AD mouse models. Brain endothelial cells (BECs) are linked together by tight junctional (TJ) proteins, which are a key de...

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Hlavní autoři: Tai, L M, Holloway, K A, Male, D K, Loughlin, A J, Romero, I A
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2010
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822747/
https://ncbi.nlm.nih.gov/pubmed/19438816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00717.x
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