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Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

c-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when deregulated. Previous studies have demonstrated a nontranscriptional role for c-Myc in regulating DNA replication. Here, we analyze the mechanisms by w...

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Hlavní autoři: Srinivasan, Seetha V., Dominguez-Sola, David, Wang, Lily C., Hyrien, Olivier, Gautier, Jean
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822004/
https://ncbi.nlm.nih.gov/pubmed/23643534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.002
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