Phage Display to Identify Nedd8-mimicking Peptides as Inhibitors of the Nedd8 Transfer Cascade

The Nedd8 activating enzyme (NAE) launches the transfer of the ubiquitin-like protein Nedd8 through an enzymatic cascade to covalently modify a diverse array of proteins, thus regulating their biological functions in the cell. The C-terminal peptide of Nedd8 extends deeply into the active site of NA...

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Hlavní autoři: Zhao, Bo, Zhang, Keya, Villhauer, Eric B., Bhuripanyo, Karan, Kiyokawa, Hiroaki, Schindelin, Hermann, Yin, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822002/
https://ncbi.nlm.nih.gov/pubmed/23824602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300234
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