Low-Dose Radiation-Induced Enhancement of Thymic Lymphomagenesis in Lck-Bax Mice is Dependent on LET and Gender

The hypothesis that mitochondrial dysfunction and increased superoxide levels in thymocytes over expressing Bax (Lck-Bax1 and Lck-Bax38&1) contributes to lymphomagenesis after low-dose radiation was tested. Lck-Bax1 single-transgenic and Lck-Bax38&1 double-transgenic mice were exposed to sin...

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Bibliographic Details
Main Authors: Jacobus, James A., Duda, Chester G., Coleman, Mitchell C., Martin, Sean M., Mapuskar, Kranti, Mao, Gaowei, Smith, Brian J., Aykin-Burns, Nukhet, Guida, Peter, Gius, David, Domann, Frederick E., Knudson, C. Michael, Spitz, Douglas R.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821998/
https://ncbi.nlm.nih.gov/pubmed/23819597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR3293.1
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