Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3

Aims: This study determined whether acute radiation-induced liver injury seen in Sirtuin3(−/−) mice after exposure to Cs-137 γ-rays was mediated by superoxide anion (O(2)(•−)). Results: Male wild-type (WT) and SIRT3(−/−) mice were given 2×2 Gy whole-body radiation doses separated by 24 h and livers...

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Detalhes bibliográficos
Main Authors: Coleman, Mitchell C., Olivier, Alicia K., Jacobus, James A., Mapuskar, Kranti A., Mao, Gaowei, Martin, Sean M., Riley, Dennis P., Gius, David, Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936509/
https://ncbi.nlm.nih.gov/pubmed/23919724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5091
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