Mitochondrial superoxide increases age-associated susceptibility of human dermal fibroblasts to radiation and chemotherapy

Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger patients. The current study demonstrates that exponentially growing fibroblasts from elderly (old) male donor subjects (70, 72, 78 years) are s...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Mapuskar, Kranti A., Flippo, Kyle H., Schoenfeld, Joshua D., Riley, Dennis P., Strack, Stefan, Hejleh, Taher Abu, Furqan, Muhammad, Monga, Varun, Domann, Frederick E., Buatti, John M., Goswami, Prabhat C., Spitz, Douglas R., Allen, Bryan G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600863/
https://ncbi.nlm.nih.gov/pubmed/28765155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0106
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