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Modulation of a Protein Free-Energy Landscape by Circular Permutation

[Image: see text] Circular permutations usually retain the native structure and function of a protein while inevitably perturbing its folding dynamics. By using simulations with a structure-based model and a rigorous methodology to determine free-energy surfaces from trajectories, we evaluate the ef...

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Bibliographische Detailangaben
Hauptverfasser: Radou, Gaël, Enciso, Marta, Krivov, Sergei, Paci, Emanuele
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821731/
https://ncbi.nlm.nih.gov/pubmed/24090448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp406818t
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