In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation

Mutated spliceosome components are recurrently being associated with perturbed tissue development and disease pathogenesis. Cephalophŏnus (cph), is a zebrafish mutant carrying an early premature STOP codon in the spliceosome component Prpf8 (pre-mRNA processing factor 8). Cph initially develops norm...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Keightley, Maria-Cristina, Crowhurst, Meredith O., Layton, Judith E., Beilharz, Traude, Markmiller, Sebastian, Varma, Sony, Hogan, Benjamin M., de Jong-Curtain, Tanya A., Heath, Joan K., Lieschke, Graham J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820954/
https://ncbi.nlm.nih.gov/pubmed/23714367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.05.030
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