Amine-reactive Neutron-encoded Labels for Highly Plexed Proteomic Quantitation

We describe a novel amine-reactive chemical label that exploits differential neutron-binding energy between (13)C and (15)N isotopes. These neutron-encoded (NeuCode) chemical labels enable up to 12-plex MS1-based protein quantification. Each structurally identical, but isotopically unique, tag is en...

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Main Authors: Hebert, Alexander S., Merrill, Anna E., Stefely, Jonathan A., Bailey, Derek J., Wenger, Craig D., Westphall, Michael S., Pagliarini, David J., Coon, Joshua J.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Technological Innovation and Resources
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820946/
https://ncbi.nlm.nih.gov/pubmed/23882030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.032011
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