Motor Domain Phosphorylation Modulates Kinesin-1 Transport

Disruptions in microtubule motor transport are associated with a variety of neurodegenerative diseases. Post-translational modification of the cargo-binding domain of the light and heavy chains of kinesin has been shown to regulate transport, but less is known about how modifications of the motor do...

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Auteurs principaux: DeBerg, Hannah A., Blehm, Benjamin H., Sheung, Janet, Thompson, Andrew R., Bookwalter, Carol S., Torabi, Seyed F., Schroer, Trina A., Berger, Christopher L., Lu, Yi, Trybus, Kathleen M., Selvin, Paul R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820893/
https://ncbi.nlm.nih.gov/pubmed/24072715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515510
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