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Binding of Complement Inhibitor C4b-binding Protein to a Highly Virulent Streptococcus pyogenes M1 Strain Is Mediated by Protein H and Enhances Adhesion to and Invasion of Endothelial Cells

Streptococcus pyogenes AP1, a strain of the highly virulent M1 serotype, uses exclusively protein H to bind the complement inhibitor C4b-binding protein (C4BP). We found a strong correlation between the ability of AP1 and its isogenic mutants lacking protein H to inhibit opsonization with complement...

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Main Authors: Ermert, David, Weckel, Antonin, Agarwal, Vaibhav, Frick, Inga-Maria, Björck, Lars, Blom, Anna M.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820857/
https://ncbi.nlm.nih.gov/pubmed/24064215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502955
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