The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to...

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Udgivet i:Front Immunol
Main Authors: Ermert, David, Laabei, Maisem, Weckel, Antonin, Mörgelin, Matthias, Lundqvist, Martin, Björck, Lars, Ram, Sanjay, Linse, Sara, Blom, Anna M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557989/
https://ncbi.nlm.nih.gov/pubmed/31214187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01230
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