RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

In most mouse tissues, long-interspersed elements-1 (L1s) are silenced via methylation of their 5′-untranslated regions (5′-UTR). A gradual loss-of-methylation in pre-implantation embryos coincides with L1 retrotransposition in blastocysts, generating potentially harmful mutations. Here, we show tha...

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Detalhes bibliográficos
Main Authors: Ciaudo, Constance, Jay, Florence, Okamoto, Ikuhiro, Chen, Chong-Jian, Sarazin, Alexis, Servant, Nicolas, Barillot, Emmanuel, Heard, Edith, Voinnet, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820764/
https://ncbi.nlm.nih.gov/pubmed/24244175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003791
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