Ash1l Methylates Lys36 of Histone H3 Independently of Transcriptional Elongation to Counteract Polycomb Silencing

Molecular mechanisms for the establishment of transcriptional memory are poorly understood. 5,6-dichloro-1-D-ribofuranosyl-benzimidazole (DRB) is a P-TEFb kinase inhibitor that artificially induces the poised RNA polymerase II (RNAPII), thereby manifesting intermediate steps for the establishment of...

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Autores principales: Miyazaki, Hitomi, Higashimoto, Ken, Yada, Yukari, Endo, Takaho A., Sharif, Jafar, Komori, Toshiharu, Matsuda, Masashi, Koseki, Yoko, Nakayama, Manabu, Soejima, Hidenobu, Handa, Hiroshi, Koseki, Haruhiko, Hirose, Susumu, Nishioka, Kenichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820749/
https://ncbi.nlm.nih.gov/pubmed/24244179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003897
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