Structure of the class B human glucagon G protein coupled receptor

Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting, thus GCGR plays an important role in glucose homeostasis. Here we report the crystal structure of the seven transmembrane (7TM) helical domain of human GCGR at 3.4 Å resolut...

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Autori principali: Siu, Fai Yiu, He, Min, de Graaf, Chris, Han, Gye Won, Yang, Dehua, Zhang, Zhiyun, Zhou, Caihong, Xu, Qingping, Wacker, Daniel, Joseph, Jeremiah S., Liu, Wei, Lau, Jesper, Cherezov, Vadim, Katritch, Vsevolod, Wang, Ming-Wei, Stevens, Raymond C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820480/
https://ncbi.nlm.nih.gov/pubmed/23863937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12393
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