Structure of the class B human glucagon G protein coupled receptor

Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting, thus GCGR plays an important role in glucose homeostasis. Here we report the crystal structure of the seven transmembrane (7TM) helical domain of human GCGR at 3.4 Å resolut...

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書誌詳細
主要な著者: Siu, Fai Yiu, He, Min, de Graaf, Chris, Han, Gye Won, Yang, Dehua, Zhang, Zhiyun, Zhou, Caihong, Xu, Qingping, Wacker, Daniel, Joseph, Jeremiah S., Liu, Wei, Lau, Jesper, Cherezov, Vadim, Katritch, Vsevolod, Wang, Ming-Wei, Stevens, Raymond C.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820480/
https://ncbi.nlm.nih.gov/pubmed/23863937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12393
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