Structure of the class B human glucagon G protein coupled receptor

Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting, thus GCGR plays an important role in glucose homeostasis. Here we report the crystal structure of the seven transmembrane (7TM) helical domain of human GCGR at 3.4 Å resolut...

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Detalhes bibliográficos
Main Authors: Siu, Fai Yiu, He, Min, de Graaf, Chris, Han, Gye Won, Yang, Dehua, Zhang, Zhiyun, Zhou, Caihong, Xu, Qingping, Wacker, Daniel, Joseph, Jeremiah S., Liu, Wei, Lau, Jesper, Cherezov, Vadim, Katritch, Vsevolod, Wang, Ming-Wei, Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820480/
https://ncbi.nlm.nih.gov/pubmed/23863937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12393
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