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Avoiding chromosome pathology when replication forks collide

Chromosome duplication normally initiates via the assembly of replication fork complexes at defined origins(1,2). DNA synthesis by any one fork is thought to cease when it meets another travelling in the opposite direction, at which stage the replication machinery may simply dissociate before the na...

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Bibliographic Details
Main Authors: Rudolph, Christian J., Upton, Amy L., Stockum, Anna, Nieduszynski, Conrad A., Lloyd, Robert G.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819906/
https://ncbi.nlm.nih.gov/pubmed/23892781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12312
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