On the significance of germline cytogenetic rearrangements at MYCN locus in neuroblastoma

BACKGROUND: MYCN oncogene amplification is the most important prognostic factor in neuroblastoma. 25% neuroblastoma tumors have somatic amplifications at this locus but little is known about its constitutional aberrations and their potential role in carcinogenesis. Here, we have performed an array-C...

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Bibliografiske detaljer
Main Authors: Lipska, Beata S, Koczkowska, Magdalena, Wierzba, Jolanta, Ploszynska, Anna, Iliszko, Mariola, Izycka-Swieszewska, Ewa, Adamkiewicz-Drozynska, Elzbieta, Limon, Janusz
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819649/
https://ncbi.nlm.nih.gov/pubmed/24131700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8166-6-43
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