Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT inhibitor that depletes NAD and induces cell death...

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Bibliografiske detaljer
Main Authors: Xiao, Yang, Elkins, Kristi, Durieux, Jenni K, Lee, Leslie, Oeh, Jason, Yang, Lulu X, Liang, Xiaorong, DelNagro, Chris, Tremayne, Jarrod, Kwong, Mandy, Liederer, Bianca M, Jackson, Peter K, Belmont, Lisa D, Sampath, Deepak, O'Brien, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819631/
https://ncbi.nlm.nih.gov/pubmed/24204194
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