Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT inhibitor that depletes NAD and induces cell death...

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Main Authors: Xiao, Yang, Elkins, Kristi, Durieux, Jenni K, Lee, Leslie, Oeh, Jason, Yang, Lulu X, Liang, Xiaorong, DelNagro, Chris, Tremayne, Jarrod, Kwong, Mandy, Liederer, Bianca M, Jackson, Peter K, Belmont, Lisa D, Sampath, Deepak, O'Brien, Thomas
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819631/
https://ncbi.nlm.nih.gov/pubmed/24204194
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