Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia

The striatal-enriched phosphatase (STEP) is a component of the NMDA-receptor-mediated excitotoxic signaling pathway, which plays a key role in ischemic brain injury. Using neuronal cultures and a rat model of ischemic stroke, we show that STEP plays an initial role in neuroprotection, during the ins...

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Autors principals: Deb, Ishani, Manhas, Namratta, Poddar, Ranjana, Rajagopal, Sathyanarayanan, Allan, Andrea M., Lombroso, Paul J., Rosenberg, Gary A., Candelario-Jalil, Eduardo, Paul, Surojit
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818554/
https://ncbi.nlm.nih.gov/pubmed/24198371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2346-12.2013
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