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Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop

Lipopolysaccharide (LPS) activates platelets through TLR4, aiding productive sepsis, with stimulated splicing and translation of stored heteronuclear pro-Interleukin-1β (IL-1β)RNA. Although the IL1R1 receptor for IL1 shares downstream components with the TLR4 receptor, platelets are not known to exp...

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Bibliografiske detaljer
Main Authors: Brown, G. Thomas, Narayanan, Padmini, Li, Wei, Silverstein, Roy L., McIntyre, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818355/
https://ncbi.nlm.nih.gov/pubmed/24081990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300354
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