EGFR T790M Mutation as a Possible Target for Immunotherapy; Identification of HLA-A*0201-Restricted T Cell Epitopes Derived from the EGFR T790M Mutation

Treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, has achieved high clinical response rates in patients with non–small cell lung cancers (NSCLCs). However, over time, most tumors develop acquired resistance to EGFR-TKIs, which is...

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Main Authors: Yamada, Teppei, Azuma, Koichi, Muta, Emi, Kim, Jintaek, Sugawara, Shunichi, Zhang, Guang Lan, Matsueda, Satoko, Kasama-Kawaguchi, Yuri, Yamashita, Yuichi, Yamashita, Takuto, Nishio, Kazuto, Itoh, Kyogo, Hoshino, Tomoaki, Sasada, Tetsuro
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818324/
https://ncbi.nlm.nih.gov/pubmed/24223798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078389
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