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Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD

CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important role of the CARMA1 signalosome during lymphoc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jang, Tae-ho, Park, Jin Hee, Park, Hyun Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818214/
https://ncbi.nlm.nih.gov/pubmed/24224005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079778
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