Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis

Apoptosis repressor with caspase recruiting domain (ARC) is a multifunctional inhibitor of apoptosis that is unusually over-expressed or activated in various cancers and in the state of the pulmonary hypertension. Therefore, ARC might be an optimal target for therapeutic intervention. Human ARC is c...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Jang, Tae-ho, Kim, Seong Hyun, Jeong, Jae-Hee, Kim, Sunghwan, Kim, Yeun Gil, Park, Hyun Ho
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453921/
https://ncbi.nlm.nih.gov/pubmed/26038885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09847
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