IL-6-STAT3 signaling mediates aortic dissections induced by angiotensin II via the Th17 lymphocyte-IL17 axis in C57BL/6 Mice

OBJECTIVE: Dysregulated angiotensin II (Ang II) signaling induces local vascular interleukin-6 (IL-6) secretion, producing leukocyte infiltration and life-threatening aortic dissections. Precise mechanism(s) by which IL-6 signaling induces leukocyte recruitment remain(s) unknown. T-helper 17lymphocy...

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Main Authors: Ju, Xiaoxi, Ijaz, Talha, Sun, Hong, Ray, Sutapa, Lejeune, Wanda, Lee, Chang, Recinos, Adrian, Guo, Dong-Chuan, Milewicz, Dianna M., Tilton, Ronald G., Brasier, Allan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818154/
https://ncbi.nlm.nih.gov/pubmed/23685554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.301049
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