AMPK-Mediated Phosphorylation of Murine p27 at T197 Promotes Binding of 14-3-3 Proteins and Increases p27 Stability

The Tuberous Sclerosis Complex 2 (TSC2) gene product, tuberin, acts as a negative regulator of mTOR signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart and lungs. Previous studies have shown that loss of tuberin function affects the stability and subcellular loc...

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Bibliografiske detaljer
Main Authors: Short, John D., Dere, Ruhee, Houston, Kevin D., Cai, Sheng-Li, Kim, Jinhee, Bergeron, Judith M., Shen, Jianjun, Liang, Jiyong, Bedford, Mark T., Mills, Gordon B., Walker, Cheryl Lyn
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818129/
https://ncbi.nlm.nih.gov/pubmed/20146253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20613
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