AMPK-Mediated Phosphorylation of Murine p27 at T197 Promotes Binding of 14-3-3 Proteins and Increases p27 Stability

The Tuberous Sclerosis Complex 2 (TSC2) gene product, tuberin, acts as a negative regulator of mTOR signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart and lungs. Previous studies have shown that loss of tuberin function affects the stability and subcellular loc...

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Detalhes bibliográficos
Main Authors: Short, John D., Dere, Ruhee, Houston, Kevin D., Cai, Sheng-Li, Kim, Jinhee, Bergeron, Judith M., Shen, Jianjun, Liang, Jiyong, Bedford, Mark T., Mills, Gordon B., Walker, Cheryl Lyn
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818129/
https://ncbi.nlm.nih.gov/pubmed/20146253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20613
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