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The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

Telomere maintenance by the conventional DNA replication machinery and telomerase is assisted by specialized DNA helicases, nucleases and telomere binding proteins. Here, we identify the THO components at telomeres and define critical roles of this complex in telomere stability. Deletion of the THO-...

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Bibliografiset tiedot
Päätekijät: Pfeiffer, Verena, Crittin, Jérôme, Grolimund, Larissa, Lingner, Joachim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: European Molecular Biology Organization 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817467/
https://ncbi.nlm.nih.gov/pubmed/24084588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.217
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