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TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends
The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length co...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375253/ https://ncbi.nlm.nih.gov/pubmed/22719262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002747 |
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