Preferential Activation of the Hedgehog Pathway by Epigenetic Modulations in HPV Negative HNSCC Identified with Meta-Pathway Analysis

Head and neck squamous cell carcinoma (HNSCC) is largely divided into two groups based on their etiology, human papillomavirus (HPV)-positive and –negative. Global DNA methylation changes are known to drive oncogene and tumor suppressor expression in primary HNSCC of both types. However, significant...

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Main Authors: Fertig, Elana J., Markovic, Ana, Danilova, Ludmila V., Gaykalova, Daria A., Cope, Leslie, Chung, Christine H., Ochs, Michael F., Califano, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817178/
https://ncbi.nlm.nih.gov/pubmed/24223768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078127
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