Alisertib (MLN8237) an Investigational Agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment

Peripheral T-cell lymphomas (PTCL) are a diverse group of rare non-Hodgkin lymphomas (NHL) that carry a poor prognosis and are in need of effective therapies. Alisertib (MLN8237) an investigational agent that inhibits Aurora A Ser/Thr kinase has shown activity in PTCL patients. Here we demonstrate t...

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Bibliografiske detaljer
Main Authors:	Qi, Wenqing, Spier, Catherine, Liu, Xiaobing, Agarwal, Amit, Cooke, Laurence S., Persky, Daniel O, Chen, Deyu, Miller, Thomas P., Mahadevan, Daruka
Format:	Artigo
Sprog:	Inglês
Udgivet:	2012
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3816641/ https://ncbi.nlm.nih.gov/pubmed/23153524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.10.017
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Alisertib (MLN8237) an Investigational Agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment

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