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Identification of Tamoxifen-Induced Coregulator Interaction Surfaces within the Ligand-Binding Domain of Estrogen Receptors
Tamoxifen is a selective estrogen receptor (ER) modulator that is clinically used as an antagonist to treat estrogen-dependent breast cancers but displays unwanted agonistic effects in other tissues. Previous studies on ERα have delineated a role of the N-terminal activation function AF-1 in mediati...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC381632/ https://ncbi.nlm.nih.gov/pubmed/15060164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3445-3459.2004 |
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