The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

The antimycobacterial compound ethambutol [Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol] is used to treat tuberculosis as well as disseminated infections caused by Mycobacterium avium. The critical target for Emb lies in the pathway for the biosynthesis of cell wall arabinogalactan, but the...

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Bibliografische gegevens
Hoofdauteurs: Belanger, A E, Besra, G S, Ford, M E, Mikusová, K, Belisle, J T, Brennan, P J, Inamine, J M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1996
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC38159/
https://ncbi.nlm.nih.gov/pubmed/8876238
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