The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis

Ethambutol (EMB) is an antimycobacterial drug used extensively for the treatment of tuberculosis caused by Mycobacterium tuberculosis. EMB targets the biosynthesis of the cell wall, inhibiting the synthesis of both arabinogalactan and lipoarabinomannan (LAM), and is assumed to act via inhibition of...

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Bibliographic Details
Main Authors: Goude, R., Amin, A. G., Chatterjee, D., Parish, T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764220/
https://ncbi.nlm.nih.gov/pubmed/19596878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00162-09
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