The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

The antimycobacterial compound ethambutol [Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol] is used to treat tuberculosis as well as disseminated infections caused by Mycobacterium avium. The critical target for Emb lies in the pathway for the biosynthesis of cell wall arabinogalactan, but the molec...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Belanger, A E, Besra, G S, Ford, M E, Mikusová, K, Belisle, J T, Brennan, P J, Inamine, J M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38159/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11919
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!