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Lentivirus vector-mediated Rho guanine nucleotide dissociation inhibitor 2 overexpression induces beta-2 adrenergic receptor desensitization in airway smooth muscle cells
BACKGROUND: Beta-2 adrenergic receptor (β(2)AR) downregulation is critical to asthma rescue therapy; however, tolerance, also known as β(2)AR or bronchodilator desensitization, mechanisms potentially resulting in life-threatening rescue treatment failure remain poorly understood. METHODS: Airway smo...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Pioneer Bioscience Publishing Company
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815716/ https://ncbi.nlm.nih.gov/pubmed/24255780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2072-1439.2013.10.07 |
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