Lentivirus vector-mediated Rho guanine nucleotide dissociation inhibitor 2 overexpression induces beta-2 adrenergic receptor desensitization in airway smooth muscle cells

BACKGROUND: Beta-2 adrenergic receptor (β(2)AR) downregulation is critical to asthma rescue therapy; however, tolerance, also known as β(2)AR or bronchodilator desensitization, mechanisms potentially resulting in life-threatening rescue treatment failure remain poorly understood. METHODS: Airway smo...

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Bibliografiske detaljer
Main Authors: Ni, Songshi, Zhang, Yanju, Wang, Haiying, Zhou, Juan, Ding, Liang, Liu, Hua
Format: Artigo
Sprog:Inglês
Udgivet: Pioneer Bioscience Publishing Company 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815716/
https://ncbi.nlm.nih.gov/pubmed/24255780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2072-1439.2013.10.07
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