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Axial Ligand Replacement Mechanism in Heme Transfer from Streptococcal Heme-Binding Protein Shp to HtsA of the HtsABC Transporter

The heme-binding protein Shp of Group A Streptococcus rapidly transfers its heme to HtsA, the lipoprotein component of the HtsABC transporter, in a concerted two-step process with one kinetic phase. Heme axial residue-to-alanine replacement mutant proteins of Shp and HtsA (Shp(M66A), Shp(M153A), Hts...

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Detalhes bibliográficos
Main Authors: Ran, Yanchao, Malmirchegini, G. Reza, Clubb, Robert T., Lei, Benfang
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815476/
https://ncbi.nlm.nih.gov/pubmed/23980583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400965u
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