A Strategy for Modulation of Enzymes in the Ubiquitin System

The ubiquitin system regulates virtually all aspects of cellular function. We report a method to target the myriad enzymes that govern ubiquitination of protein substrates. We used massively diverse combinatorial libraries of ubiquitin variants to develop inhibitors of four deubiquitinases (DUBs) an...

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Detalhes bibliográficos
Main Authors: Ernst, Andreas, Avvakumov, George, Tong, Jiefei, Fan, Yihui, Zhao, Yanling, Alberts, Philipp, Persaud, Avinash, Walker, John R, Neculai, Ana-Mirela, Neculai, Dante, Vorobyov, Andrew, Garg, Pankaj, Beatty, Linda, Chan, Pak-Kei, Juang, Yu-Chi, Landry, Marie-Claude, Yeh, Christina, Zeqiraj, Elton, Karamboulas, Konstantina, Allali-Hassani, Abdellah, Vedadi, Masoud, Tyers, Mike, Moffat, Jason, Sicheri, Frank, Pelletier, Laurence, Durocher, Daniel, Raught, Brian, Rotin, Daniela, Yang, Jianhua, Moran, Michael F, Dhe-Paganon, Sirano, Sidhu, Sachdev S
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815447/
https://ncbi.nlm.nih.gov/pubmed/23287719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1230161
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