Kinetic Intermediates en Route to the Final Serpin-Protease Complex: STUDIES OF COMPLEXES OF α(1)-PROTEASE INHIBITOR WITH TRYPSIN

Serpin protein protease inhibitors inactivate their target proteases through a unique mechanism in which a major serpin conformational change, resulting in a 70-Å translocation of the protease from its initial reactive center loop docking site to the opposite pole of the serpin, kinetically traps th...

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Detalhes bibliográficos
Main Authors: Maddur, Ashoka A., Swanson, Richard, Izaguirre, Gonzalo, Gettins, Peter G. W., Olson, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814797/
https://ncbi.nlm.nih.gov/pubmed/24047901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510990
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