Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

The ubiquitination of NEMO with linear ubiquitin chains by the E3-ligase LUBAC is important for the activation of the canonical NF-κB pathway. NEMO ubiquitination requires a dual target specificity of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiquitin....

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Dettagli Bibliografici
Autori principali: Smit, Judith J., van Dijk, Willem J., El Atmioui, Dris, Merkx, Remco, Ovaa, Huib, Sixma, Titia K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814767/
https://ncbi.nlm.nih.gov/pubmed/24030825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495846
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