Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier

Cannabinoid receptor 2 (CB2) is highly expressed in immune cells and stimulation decreases inflammatory responses. We tested the idea that selective CB2 activation in human monocytes suppresses their ability to engage the brain endothelium and migrate across the blood-brain barrier (BBB), preventing...

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Hlavní autoři: Rom, Slava, Zuluaga-Ramirez, Viviana, Dykstra, Holly, Reichenbach, Nancy L., Pacher, Pal, Persidsky, Yuri
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2013
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814716/
https://ncbi.nlm.nih.gov/pubmed/24055259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.07.033
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