An abnormal Ca(2+) response in mutant sarcomere protein–mediated familial hypertrophic cardiomyopathy

Dominant-negative sarcomere protein gene mutations cause familial hypertrophic cardiomyopathy (FHC), a disease characterized by left-ventricular hypertrophy, angina, and dyspnea that can result in sudden death. We report here that a murine model of FHC bearing a cardiac myosin heavy-chain gene misse...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Fatkin, Diane, McConnell, Bradley K., Mudd, James O., Semsarian, Christopher, Moskowitz, Ivan G.P., Schoen, Frederick J., Giewat, Michael, Seidman, Christine E., Seidman, J.G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2000
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11104788/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11093
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