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An age-related numerical and functional deficit in CD19(+)CD24(hi)CD38(hi) B cells is associated with an increase in systemic autoimmunity
Autoimmunity increases with aging indicative of reduced immune tolerance, but the mechanisms involved are poorly defined. In recent years, subsets of B cells with immunoregulatory properties have been identified in murine models of autoimmune disorders, and these cells downregulate immune responses...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814412/ https://ncbi.nlm.nih.gov/pubmed/23755918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12114 |
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