An age-related numerical and functional deficit in CD19(+)CD24(hi)CD38(hi) B cells is associated with an increase in systemic autoimmunity

Autoimmunity increases with aging indicative of reduced immune tolerance, but the mechanisms involved are poorly defined. In recent years, subsets of B cells with immunoregulatory properties have been identified in murine models of autoimmune disorders, and these cells downregulate immune responses...

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Hlavní autoři: Duggal, Niharika A, Upton, Jane, Phillips, Anna C, Sapey, Elizabeth, Lord, Janet M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814412/
https://ncbi.nlm.nih.gov/pubmed/23755918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12114
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